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A Regular Seminar(May 14)
 
학과사무실 2014-05-12 15:40:04
kubhj@kinkuk.ac.kr 2014-05-12 15:40:04
 
 




1. Date : 2014년 5월 14일 오후 5시



2. Venue : 605,Institute of Biomedical Science and Technology



3. Speaker : Jongseon Choe
Kangwon National University School of Medicine, Chuncheon, Gangwon, Republic of Korea




4. Title



Regulation of prostaglandin production in human follicular dendritic cells: unexpected role of SOCS1





5. Abstract



Prostaglandins (PGs) are emerging as important immune mediators. Since our first report on the expression of prostacyclin synthase in the germinal centers, we have investigated production mechanisms and biological functions of PG using human follicular dendritic cell (FDC)-like cells. In our previous reports, we observed that TGF-beta enhanced PG production and COX-2 protein expression in a time- and dose-dependent manner. Here, we explored the regulation mechanism of PG production by TGF-beta using siRNA technology. Although TGF-beta induced phosphorylation of both Smad2 and Smad3, only Smad3 was necessary for TGF-beta-stimulated COX-2 induction and PG production. TGF-beta also induced phosphorylation of Erk and p38 MAP kinases, which were required for the TGF-beta-stimulated COX-2 induction. Unexpectedly, we found that SOCS1 played a positive regulatory role in TGF-beta-promoted COX-2 upregulation. The critical role of SOCS1 was demonstrated by both SOCS1 depletion and overexpression. Confocal microscopy and SOCS1 overexpression experiment confirmed this novel finding. As the name implies, SOCS molecules were largely regarded as a negative regulator of cytokine signaling. Our novel data provide a new insight into the biological function and application of SOCS molecules


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